Comparative Degenerative Liver with Amalar, Chloroquine, Cotecxin and Fansidar

A comparative histologic effects of chloroquine, fansidar, amalar and cotecxin on the liver was carried out on thirty (30) male and female albino rats for the period of twenty eight days (28) days. The liver with chloroquine administration showed congestion of the central veins and the pericentral hepacytes had mild degeneration as against the control group without the drug. However, in the fansidar drug group there was no dilation of the pericentral hepatocytes nor congestion and degenerative changes though the central veins were dilated. But the liver with cotecxin administration showed veinous dilation, congestion and infiltration of inflammatory cells into the central veins not seen in the control group. On the other hand, the liver’s reaction to amalar drug only resulted in mild congestion of the central veins. It is shown in the study that cotecxin and chloroquine curative antimalarials continuous intake may cause liver cirrhosis. Copyright © WJMMS, all rights reserved.